الوصف
Background Information：
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the
nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the
polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at
the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to
cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at
least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the
kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
المراجعات
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