الوصف
Background Information：
Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic
alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the
production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds.Subcellular Location :
Microsome membrane. Endoplasmic reticulum membrane.Tissue Specificity : Liver.Post-translational modifications : Belongs to the
FMO family.DISEASE : Defects in FMO3 are the cause of trimethylaminuria (TMAU) [MIM:602079]; also known as fish-odor
syndrome. TMAU is an inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated
N-oxidation of amino-trimethylamine (TMA) derived from foodstuffs. Such individuals excrete relatively large amounts of TMAin their
urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine.Similarity : Belongs to the FMO
family. Database links : UniProtKB/Swiss-Prot: P31513.5
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